Information freedom for open source users.

BraveHeart writes “Researchers have long known that mammals, including humans, lack a key enzyme — one possessed by most of the animal kingdom and even plants — that reverses severe sun damage. For the first time, researchers have witnessed how this enzyme works at the atomic level to repair sun-damaged DNA. ‘Normal sunscreen lotions convert UV light to heat, or reflect it away from our skin. A sunscreen containing photolyase could potentially heal some of the damage from UV rays that get through.’”

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Dr. Eggman writes “Nature Medicine brings us news of the latest success in the regeneration of the gas exchanging tissues [abstract is free; the full paper requires subscription or payment] of the lungs of a rat. Led by Harald C. Ott, researchers from Massachusetts General Hospital and Harvard Medical School in Boston used decellularization to produce a cellular scaffolding to serve as the basis of the transplant lungs. You may recall the previous achievements in use of this cellular scaffolding technique by Yale University. This latest announcement comes with the excellent news that the rat’s airway and respiratory muscles performed the necessary ventilation (as a normal rat’s would,) and that they provided gas exchange for up to 6 hours after extubation, up from the previous 2 hours. They eventually failed due to capillary leakage resulting in the accumulation of fluids in the lungs. Although there’s much work to be done, as not all the cell types found in the lung were regenerated, Ott and his team remain optimistic and estimated we might see regenerated organs for use in human patients within 5 to 10 years.”

PhysOrg has videos of the lungs doing their thing.

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Gisg writes “The University of Arizona team reported that their genetically modified mosquitoes are immune to the malaria-causing parasite, a single-cell organism called Plasmodium. Riehle and his colleagues tested their genetically-altered mosquitoes by feeding them malaria-infested blood. Not even one mosquito became infected with the malaria parasite.”

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cremeglace writes “A quarter-century of conventional detective work failed to track down the killer responsible for the deaths of at least 10 young women in south Los Angeles dating back to the mid-1980s. But a discarded piece of pizza and a relatively new method of DNA testing has finally cracked the case, police announced last week. On July 7, L.A. police arrested Lonnie Franklin Jr., 57, a former garage attendant and sanitation worker they suspect is the serial killer nicknamed the ‘Grim Sleeper.’ The key evidence? A match between crime-scene DNA and the suspect’s son, obtained by a search through the state’s data bank of DNA collected from 1.3 million convicted felons.”

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An anonymous reader sends this clip from Scienceblog.com. “Scientists have discovered two potent human antibodies that can stop more than 90 percent of known global HIV strains from infecting human cells in the laboratory, and have demonstrated how one of these disease-fighting proteins accomplishes this feat. … Research efforts to find individual antibodies that can neutralize HIV strains have been difficult because the virus continuously changes its surface proteins to evade recognition by the immune system. As a consequence of these changes, an enormous number of HIV variants exist worldwide. However, there are a few surface areas that remain nearly constant across all variants of HIV and scientists have now discovered two potent human antibodies that attach to one of these sites and can stop more than 90 percent of known global HIV strains from infecting human cells in the laboratory. … The researchers also confirmed that VRC01 does not bind to human cells — a characteristic that might otherwise lead to its elimination during immune development, a natural mechanism the body employs to prevent autoimmune disease.”

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hankwang writes “Dutch chemical company DSM announced a new process for production of ethanol from agricultural waste. Most bio-fuel ethanol now is produced from food crops such as corn and sugar cane. Ethanol produced from cellulose would use waste products such as wood chips, citrus peel, and straw. The new process is claimed to increase the yield by a factor of two compared to existing processes, thanks to new enzymes and special yeast strains.”

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suraj.sun passes along news from Oregon State University, where researchers have discovered a new strain of bacteria that may be able to aid cleanup efforts in the Gulf of Mexico. The bacteria “can produce non-toxic, comparatively inexpensive ‘rhamnolipids,’ and effectively help degrade polycyclic aromatic hydrocarbons, or PAHs — environmental pollutants that are one of the most harmful aspects of oil spills. Because of its unique characteristics, this new bacterial strain could be of considerable value in the long-term cleanup of the massive Gulf Coast oil spill, scientists say.” In related news, Kevin Costner’s centrifugal separator technology has gotten approval for deployment; now it is only waiting on funding from BP.

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An anonymous reader writes “The sci-fi movie Splice seems to have scared the Ohio’s State Senator Steve Buehrer. The Ohio Senate has passed Sen. Buehrer’s bill banning ‘the creation, transportation, or receipt of a human-animal hybrid, the transfer of a nonhuman embryo into a human womb, and the transfer of a human embryo into a nonhuman womb.’ So much for Teenage Mutant Ninja Turtles.”

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asukasoryu writes “Man and machine can now be linked more intimately than ever, according to a new article in the journal ACS Nano Letters. Scientists have embedded a nano-sized transistor inside a cell-like membrane and powered it using the cell’s own fuel. To create the implanted circuit, the UC scientists combined a carbon nanotube transistor, lipid bilayer coating, ion pump, and ATP. The ion pump changes the electrical charge inside the cell, which then changes the electrical charge going through the transistor, which the scientists could measure and monitor.”

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An anonymous reader writes “It sounds like a cool — if somewhat pointless — super-powered insect: a fly that can smell light! Researchers added a light-sensitive protein to a fruit fly’s olfactory neurons, which caused the neurons to fire when the fly was exposed to a certain wavelength of blue light. Adding the protein specifically to neurons that respond to good smells, like bananas, makes for a light-seeking fly.”

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An anonymous reader writes “Pioneer and veteran of genomics, Professor John Sulston, is extremely concerned about the patent applications on the first synthetic life-form. The patents were filed by the Venter Institute following the announcement of the first life-form to have a synthetic genome. Sulston claims the patent is excessively broad and would stifle research and development in the field by creating an effective monopoly on synthetic life and related molecular techniques. Prof. Sulston had previously locked horns ten years ago with Dr. Craig Venter over intellectual property issues surrounding the human genome project. Fortunately, Sulston won the last round and the HGP is freely accessible — Venter had wanted to charge for access, just as he now wishes to make ‘synthetic life’ proprietary.”

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eldavojohn writes “It’s a classic case that comes up when dealing with patents. A hospital’s research on the donated brains of deceased children has been in limbo for three years because of a challenge from a patent holder. The double-edged sword of patents that spurred investment into the field will also cause chilling effects on research like the case of the Children’s Hospital of Orange County. They’ve now been forced to shift the money from the lab to lawyers in order to deal with this ongoing patent dispute over a technique that was developed to extract stem cells at the Salk Institute. Unfortunately the Salk Institute failed to patent the technology, so a company named StemCells happily had it approved. The real disheartening news is that CHOC’s Dr. Philip H. Schwartz — the doctor collecting the cells — was one of the original researchers who helped developed this technique at the Salk Institute. Now he can’t even use the technique he helped create. Schwartz has since been instructed not to publicly discuss the case further. Research interests are clashing with commercial interests in a classic case that causes one to wonder if patents surrounding medical techniques like this stretch too far. As for the people that donated their dead child’s brain to research, those valuable stem cell cultures have been kept in storage instead of being disseminated to research labs (who desperately need them) across the country.”

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Socguy writes “With the announcement earlier this week that a team of researchers has created the first artificial life, The Economist has been pondering the implications of what this brave new frontier means when the power to build living organisms filters through to anyone with a laptop. Traditional methods of restricting and regulating dangerous technology have more or less worked so far, but the Economist thinks that this time may be different. They are calling for an open system where the ‘good guys’ can see and counter any dangerous organisms that are released, accidentally or otherwise.”

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An anonymous reader writes “The organizers of the game Foldit, where you fold proteins for scientific research, announced that a user has found a protein that may be able to bind influenza viruses. Researchers plan to test the protein in a lab over the next few weeks to see if it might be medically useful.”

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nj_peeps writes “Science fiction is fraught with mad scientists who discover strange chemicals that can empower the human body or even reanimate the dead. Well, Harvard has come about as close to that scenario as anyone would want them to. Prof. Hemant Thatte has developed a cocktail of 21 chemical compounds that he calls Somah, derived from the Sanskrit for ‘ambrosia of rejuvenation.’ Using Somah, Thatte and his team have accomplished some amazing feats with pig hearts. They can keep the organ viable for transplant up to 10 days after harvest – that’s incredibly longer than the 4-hour limit seen in hospitals today. Not only that, but using low temperatures and Somah, they were able to take a pig heart that was removed post mortem and get it to beat 24 hours later in the lab.”

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Lanxon writes “A team of researchers at the Royal Veterinary College in London has built a ‘cyber-cockroach’ (a cockroach wearing an accelerometer in a tiny backpack) to try and better understand the movements of many-legged animals. They found that unlike bipedal creatures, animals with more than two legs don’t adjust their movements when walking over a softer surface.”
The academic paper is available from the Journal of Experimental Biology. This research will be helpful in finding better ways for multi-legged robots to navigate difficult terrain.

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Lanxon writes “A team of researchers at the Royal Veterinary College in London has built a ‘cyber-cockroach’ (a cockroach wearing an accelerometer in a tiny backpack) to try and better understand the movements of many-legged animals. They found that unlike bipedal creatures, animals with more than two legs don’t adjust their movements when walking over a softer surface.”
The academic paper is available from the Journal of Experimental Biology. This research will be helpful in finding better ways for multi-legged robots to navigate difficult terrain.

Read more of this story at Slashdot.

separsons writes “Researchers at Duke University recently used DNA to craft tiny chips used in computers and electronic circuits. By mixing DNA snippets with other molecules and exposing them to light, researchers created self-assembling, DNA-based logic circuits. Once perfected the tech could serve as an endlessly abundant, cheap alternative to silicon semiconductors. Chris Dwyer, lead researcher on the project, says that one grad student using DNA to make self-assembling circuits could produce more logic circuits in one day than the global silicon chip industry can create in an entire month!”

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Hugh Pickens writes “The Chicago Sun-Times reports that Walgreens is slated to begin selling genetic-testing kits priced from $20 to $30 apiece that can tell people whether they’re likely to get breast cancer, Alzheimer’s disease, become obese, or suffer from a range of other maladies. However, to get the results of various tests, shoppers will have to fork over an additional $79 for drug-response results, $179 for ‘pre-pregnancy planning’ results, $179 for health condition results, or $249 for a combination of the three. Pathway Genomics and other companies already offer such tests online, but Walgreens will be the first brick-and-mortar retailer to sell them. FDA spokeswoman Karen Riley says Pathway overstepped its bounds when it announced its plans to market the tests directly to the consumer at 6,000 of Walgreen’s 7,500 stores and wants Pathway Genomics to submit data showing that its tests give accurate results. ‘The claims have limitations based on existing science,’ says Riley, ‘and consumers should not be making important medical and lifestyle decisions based on these tests without first consulting a health-care professional.’ Walgreen responded that FDA clearance is not required to sell the kit in its stores; and anyway, the drugstore chain already sells other diagnostic and testing products such as pregnancy tests, paternity tests, and drug tests.”

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separsons writes “Researchers at the Lawrence Livermore National Laboratory recently unveiled a three-inch-long bio-detector than can scan for 3,000 different types of viruses and bacteria in just 24 hours. The device, dubbed the Lawrence Livermore Microbial Detection Array (LLMDA), boasts significant advantages over traditional bio-detectors, which can only identify a maximum of 50 pathogens. The three-inch-long glass slide is packed with 388,000 probes that can detect more than 2,000 viruses and 900 bacteria. The device may have huge implications in identifying agents released during biological and chemical attacks. Plus, in more everyday uses, LLMDA can ensure food, drug and vaccine safety and help diagnose medical problems. Scientists’ next version of LLMDA is even more impressive: A new bio-detector will be lined with 2.1 million probes that can scan for 5,700 viruses and thousands of bacteria as well as fungi and protozoa.”

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